The Benefits of Autophagy & Ketosis

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A gentle detox bath is a excellent way to relax and eliminate some toxins in the body. But if you would like to get serious about detoxing, autophagy is the way to go. This cleansing process is an wonderful approach support cellular homeostasis and to better health.

The Benefits of Autophagy & Ketosis

What’s Autophagy?

Autophagy is a body process that translates as”self-eating.” The word comes from the Greek words auto (self) and phagy (eating).

This detox process involves the body using parts to make new cell formation. Since it recycles”crap” cells initially, autophagy is a procedure that helps improve overall health.

In 2016, the Nobel Prize was won by Japanese scientist Yoshinori Ohsumi for his discoveries. This study has paved the way for a better understanding of diseases and the role of autophagy in fighting with them.

Unsurprisingly, scientists have found that disruption of autophagy may result in disease including neurodegeneration, cancer, diabetes, liver disease, autoimmune diseases, and infections, according to the 2010 study and others. How Does Autophagy Work?

The detox process of autophagy is triggered by stressors on the body, but researchers wanted to understand how these stressors triggered this self cleansing procedure.

In a study published in Nature Communications, researchers found that a protein (p62) is responsible for inducing autophagy. Reactive oxygen species (ROS), which is a metabolic by-product, trigger p62 to begin cleaning out old junky parts. This is a survival mechanism that will help cells. Autophagy is a process that will help reduce the harm of stress.

In the study, researchers created a genetically modified fruit flies with the component of p62 responsible for autophagy. Fruit flies do not normally have the ability to cleanse themselves through autophagy. These flies that were modified lived longer under conditions without the protein. Researchers reasoned that autophagy may be a key to reducing illness and other issues surrounding the aging procedure.Advantages of Autophagy

Autophagy is an procedure that the body relies on for health. Since it recycles old or dysfunctional material, autophagy helps the body to function during nutrient deprivation (starvation, fasting, ketosis, etc). Essentially, the body can use old proteins for fuel in a time that no protein is coming to the body.

Autophagy induces cell death, and prevents the accumulation of cellular components within the body, particularly mitochondria.

Autophagy has many other advantages:

Promising Against Cancer

A 2012 study found that autophagy is the body is beneath. The research goes on to explain that this adaptability makes autophagy an important part of fending off cancer and disturbance of autophagy may cause cancerous disease. Yet, another study published in Clinical Cancer Research discovered some cancers depend on autophagy for survival and that suppressing autophagy is a better therapy for those cancers. This information demonstrates that this is.

Heart Health

According to a study published in Circulation Research heart disease caused by age is usually characterized by”hypertrophy, fibrosis, and accumulation of misfolded proteins and dysfunctional mitochondria.” Autophagy although autophagy is an integral component of removing these materials that are dysfunctional diminishes with age. Thus, it is logical that increasing autophagy might help improve heart issues that are age-related. The study explains that this is accurate. In mouse studies, eliminating dysfunctional materials improves the cellular environment and thus heart health.


Autophagy is a procedure for protein homeostasis and cell health. Experts and researchers are starting to agree that autophagy in the body’s shortage is a contributor to neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Improving autophagy in the body could then reduce the chance of developing Alzheimer’s disease or may be key in reversing it.

Increase Longevity

Autophagy is a survival process that makes it possible for people to survive and even thrive in stressful conditions. As a result of this, autophagy can help increase longevity. But researchers are not completely clear on how affects longevity and conclude that more research is needed to find out.How to Induce Autophagy

When the body is under just enough stress to cause a reaction, autophagy is triggered. There are 3 main ways


Restricting eating for a certain amount of time is 1 way to induce. According to Dr. Daniel Pompa inside this podcast episode, day 3 and 4 of a water fast is where autophagy starts to kick in. When I did a 7-day water fast (nothing but clean water), I discovered that times 3-4 I felt the worst but then bounced back with plenty of energy soon after.

There are some ways, if you are not ready for a 3-7 day fast you can Find some of the same advantages:

  • Intermittent fasting — Intermittent fasting is where you eat less frequently (but not less meals ). The nighttime when we are asleep is a time. That time is stretched by intermittent fasting . By way of example, you might have dinner at 8 pm and not eat again until breakfast at noon the following day. Many experts believe of ingesting the greater the window. They suggest a goal of a 4-8 hour eating window.
  • Time-restricted eating (TRE) — This is very similar to intermittent fasting but also has a circadian rhythm element to it. TRE advocates eating when the body is more able to handle food (earlier in the day) and stopping eating by dark when the human body and metabolism are winding down. With TRE an program might be eating dinner and not eating again until 8 am the following morning.
  • Working up to a fast — If you are concerned about jumping into a fast, you can gradually work your way up. Step one eliminating snacks and will be eating 3 meals daily. Next, you could work to make your fasting time more (12 hours to begin ) and possibly cut down to two meals in a 4-8 hour eating window.

There are a number of ways to fast including juice fasting and broth fasting, but Dr. Pompa recommends a water fast for the best results.


It’s not always possible while fasting has many advantages beyond activating autophagy. But you can be given many of the same benefits by ketosis.

Ketosis is a state where your body is using fat as fuel rather than glucose (like during fasting). But ketosis can be achieved without eliminating all food. Instead, you eat a high fat, moderate protein, low carb diet, like a ketogenic diet.

This kind of diet reduces carbs so the body is forced to begin using fat. Since burns cleaner that carbs and autophagy will begin to function to recycle old material, entering ketosis can have a huge impact on health.

Dr. Pompa recommends finding something that works for you. For some people, a keto diet every day may not be attainable. He mentions that some women find they function better if they then go back to a very low carb diet after and consume more carbs during the week of their period. Others find that a diet 6 days per week and a carbohydrate day once a week helps alleviate symptoms but provides them the advantages of a keto diet.

How to Test

I have used a meter like Keto Mojo to know for certain if I am in ketosis or not. It measures a drop of blood and tests blood ketone levels. Levels of 0.5-1.5 mmol/L are considered nutritional ketosis, and 1.5-3 mmol/L is considered optimal for fat burning and possibly autophagy.

I have managed to change in and out of ketosis even after a overnight fast, as my body has adapted.


There are many advantages to exercise so it’s not a surprise that it may also help autophagy. In actuality, researchers have a 2012 study agree that autophagy is responsible for the advantages of exercise. Exercise induces in body organs including muscle, pancreas, liver and adipose tissue.

It’s unclear exactly what kind of exercise and how much is beneficial. However, high-intensity interval training (HIIT) has been demonstrated to enhance mitochondrial function. Additionally, a study published in Aging discovered that resistance training helped.

But any exercise should provide some benefit, so simply get moving!


I have talked about the health benefits of sauna use before, and it looks like one reason it’s so valuable is that it may stimulate autophagy. Research published in Science Daily affirms that sauna can enhance cellular health by triggering autophagy. The reason is that the heat from a sauna causes some stress . (I urge this podcast if you wish to find out more.)Bottom Line: Autophagy for Detox

The body is smart although complex, but amazing. Autophagy is a way that the body has adapted to enhancing health and dealing with stressors. What is even more exciting about using to improve health is that it’s available to everyone. There’s no need to buy high-priced supplements or equipment! Inducing is as straightforward as creating.